T-2 toxin enhances catabolic activity of hypertrophic chondrocytes through ROS-NF-κB-HIF-2α pathway

► T-2 Toxin enhanced catabolic gene expression in hypertrophic chondrocytes. ► HIF-2α was a crucial mediator in T-2 toxin treatment. ► T-2 Toxin induced the degradation of IκB-α and the production of ROS. ► We confirmed that ROS-NF-κB-HIF-2α pathway participated in the process.