The androgenic anabolic steroid tetrahydrogestrinone produces dioxin-like effects via the aryl hydrocarbon receptor

► Tetrahydrogestrinone (THG) induces the dioxin response element (DRE) activity. ► THG increased expression and enzymatic activity of cytochrome P-450 1A1 (CYP1A1). ► THG induces these dioxin-like effects through aryl hydrocarbon receptor.