کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5866723 | 1563483 | 2014 | 6 صفحه PDF | دانلود رایگان |
BackgroundAntibiotics used to reduce nasal colonization by Staphylococcus aureus in patients before admission are inappropriate for carriage reduction on a regular basis within a hospital community. Effective nonantibiotic alternatives for daily use in the nares will allow reduction of this bacterial source to be addressed.MethodsOur study tested the effectiveness of a nonantibiotic, alcohol-based antiseptic in reducing nasal bacterial carriage in health care professionals (HCPs) at an urban hospital center. HCPs testing positive for vestibular SÂ aureus colonization were treated 3 times during the day with topical antiseptic or control preparations. Nasal SÂ aureus and total bacterial colonization levels were determined before and at the end of a 10-hour workday.ResultsSeventy-eight of 387 HCPs screened (20.2%) tested positive for SÂ aureus infection. Of 39 subjects who tested positive for SÂ aureus infection who completed the study, 20 received antiseptic and 19 received placebo treatment. Antiseptic treatment reduced SÂ aureus colony forming units from baseline by 99% (median) and 82% (mean) (PÂ <Â .001). Total bacterial colony forming units were reduced by 91% (median) and 71% (mean) (PÂ <Â .001).ConclusionsNasal application of a nonantibiotic, alcohol-based antiseptic was effective in reducing SÂ aureus and total bacterial carriage, suggesting the usefulness of this approach as a safe, effective, and convenient alternative to antibiotic treatment.
Journal: American Journal of Infection Control - Volume 42, Issue 8, August 2014, Pages 841-846