کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5867541 | 1563463 | 2016 | 5 صفحه PDF | دانلود رایگان |
- The effectiveness of late occupational PEP for HBV after 24Â hours was not known.
- A retrospective analysis was done with data from 143 cases of HCWs in Korea.
- No case of seroconversion of HBsAg was found even in late HBV PEP group.
- HBIG administered between 24Â hours and 7Â days of post-exposure may not be harmful.
BackgroundPostexposure prophylaxis for occupational exposure to hepatitis B virus (HBV) plays an important role in the prevention of HBV infections in health care workers (HCWs). We examined data concerning the acceptable duration between occupational exposure and administration of a hepatitis B immunoglobulin (HBIG) injection in an occupational clinical setting.MethodsA retrospective analysis was conducted with data from 143 cases of HCWs exposed to HBV in 15 secondary and tertiary teaching hospitals between January 2005 and June 2013. Data were taken from the infection control records of each hospital.ResultsActive vaccination after HBV exposure was started in 119 cases (83.2%) and postvaccination testing for hepatitis B antibody showed positive seroconversion in 93% of cases. In 98 cases (68.5%), HBIG was administered within 24Â hours after HBV exposure; however, 45 HCWs (31.5%) received an HBIG injection more than 24Â hours postexposure and 2 among the 45 received an injection after 7Â days. Although 31.5% received an HBIG injection more than 24Â hours postexposure, no cases of seroconversion to hepatitis b antibody positivity occurred.ConclusionsFor susceptible HCWs, HBIG administered between 24Â hours and 7Â days postexposure may be as effective as administration within 24Â hours in preventing occupational HBV infection.
Journal: American Journal of Infection Control - Volume 44, Issue 2, 1 February 2016, Pages 189-193