کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5888881 1568132 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bone targeted therapy for preventing skeletal-related events in metastatic breast cancer
ترجمه فارسی عنوان
استخوان درمان هدفمند برای جلوگیری از حوادث مربوط به اسکلت در سرطان متاستاتیک پستان است
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی


- Bone targeted therapy reduces incidence and delays the occurrence of the SREs
- Zoledronic acid produces a significant advantage compared to pamidronate and ibandronate in reducing the incidence of SREs
- Denosumab is superior to zoledronic acid in preventing or delaying the SREs and improving the quality of life

Cancer cells can alter physiological mechanisms within bone resulting in high bone turnover, and consequently in skeletal-related events (SREs), causing severe morbidity in affected patients. The goals of bone targeted therapy, as bisphosphonates and denosumab, are the reduction of incidence and the delay in occurrence of the SREs, to improve quality of life and pain control.The toxicity profile is similar between bisphosphonates and denosumab, even if pyrexia, bone pain, arthralgia, renal failure and hypercalcemia are more common with bisphosphonates, while hypocalcemia and toothache are more frequently reported with denosumab. Osteonecrosis of the jaw (ONJ) occurred infrequently without statistically significant difference.The present review aims to provide an assessment on bone targeted therapies for preventing the occurrence of SREs in bone metastatic breast cancer patients, critically analyzing the evidence available so far on their effectiveness, in light of the different mechanisms of action. Thus, we try to provide tools for the most fitting treatment of bone metastatic breast cancer patients.We also provide an overview on the usefulness of bone turnover markers in clinical practice and new molecules currently under study for the treatment of bone metastatic disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 87, June 2016, Pages 169-175
نویسندگان
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