The effect of chronic mild hyponatremia on bone mineral loss evaluated by retrospective national Danish patient data

Chronic mild hyponatremia seems to greatly affect bone in the hip, while the effect is limited in the lumbar spine. We suggest further retrospective study of patients with moderate (P-Na = 120-130 mmol/L) to severe hyponatremia (P-Na < 120 mmol/L) and prospective studies to further examine the association.