کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5889681 1568142 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Deficits in bone density and structure in children and young adults following Fontan palliation
ترجمه فارسی عنوان
نقص در تراکم و ساختار استخوان در کودکان و نوجوانان پس از تخلیه فونتان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی


- Patients with single ventricle heart disease are at risk for impaired bone accrual.
- Quantitative CT was used to assess bone in Fontan participants and controls.
- Fontan participants had lower trabecular density and smaller cortical dimensions.
- Calf muscle area was also significantly lower in Fontan participants.
- Lower muscle area was associated with smaller periosteal circumference.

BackgroundSurvival of patients with congenital heart disease has improved such that there are now more adults than children living with these conditions. Complex single ventricle congenital heart disease requiring Fontan palliation is associated with multiple risk factors for impaired bone accrual. Bone density and structure have not been characterized in these patients.MethodsTibia peripheral quantitative computed tomography (pQCT) was used to assess trabecular and cortical volumetric bone mineral density (vBMD), cortical dimensions, and calf muscle area in 43 Fontan participants (5-33 years old), a median of 10 years following Fontan palliation. pQCT outcomes were converted to sex- and race-specific Z-scores relative to age based on > 700 healthy reference participants. Cortical dimensions and muscle area were further adjusted for tibia length.ResultsHeight Z-scores were lower in Fontan compared to reference participants (mean ± SD: − 0.29 ± 1.00 vs. 0.25 ± 0.93, p < 0.001); BMI Z-scores were similar (0.16 ± 0.88 vs. 0.35 ± 1.02, p = 0.1). Fontan participants had lower trabecular vBMD Z-scores (− 0.85 ± 0.96 vs. 0.01 ± 1.02, p < 0.001); cortical vBMD Z-scores were similar (− 0.17 ± 0.98 vs. 0.00 ± 1.00, p = 0.27). Cortical dimensions were reduced with lower cortical area (− 0.59 ± 0.84 vs. 0.00 ± 0.88, p < 0.001) and periosteal circumference (− 0.50 ± 0.82 vs. 0.00 ± 0.84, p < 0.001) Z-scores, compared to reference participants. Calf muscle area Z-scores were lower in the Fontan participants (− 0.45 ± 0.98 vs. 0.00 ± 0.96, p = 0.003) and lower calf muscle area Z-scores were associated with smaller periosteal circumference Z-scores (R = 0.62, p < 0.001). Musculoskeletal deficits were not associated with age, Fontan characteristics, parathyroid hormone or vitamin D levels.ConclusionsChildren and young adults demonstrate low trabecular vBMD, cortical structure and muscle area following Fontan. Muscle deficits were associated with smaller periosteal dimensions. Future studies should determine the fracture implications of these deficits and identify interventions to promote musculoskeletal development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 77, August 2015, Pages 12-16
نویسندگان
, , , , , , , , , ,