The influence of disuse on bone microstructure and mechanics assessed by HR-pQCT

Our results suggest that detectable microstructural and biomechanical degradation occurs - particularly within the cortical compartment - as a result of non WB and persists following return to normal loading. A better understanding of these microstructural changes and their short- and long-term influence on biomechanics may have clinical relevance in the context of disuse-related fracture prevention.