کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5890497 | 1568160 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of age on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in humans
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of age on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in humans Effects of age on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in humans](/preview/png/5890497.png)
چکیده انگلیسی
Our findings thus indicate that despite increases in circulating sclerostin levels, bone sclerostin mRNA levels do not increase in elderly women. However, aging is associated with alterations in several key pathways and genes in humans that may contribute to the observed impairment in bone formation. These include notch signaling, which represents a potential therapeutic target for increasing bone formation in humans. Our studies further identified mRNA levels of SFRP1 as being increased in aging bone in humans, suggesting that this may also represent a viable target for the development of anabolic therapies for age-related bone loss and osteoporosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 59, February 2014, Pages 1-6
Journal: Bone - Volume 59, February 2014, Pages 1-6
نویسندگان
Matthew M. Roforth, Koji Fujita, Ulrike I. McGregor, Salman Kirmani, Louise K. McCready, James M. Peterson, Matthew T. Drake, David G. Monroe, Sundeep Khosla,