miR-155 modulates TNF-α-inhibited osteogenic differentiation by targeting SOCS1 expression

► TNF-α suppresses osteogenic differentiation. ► miR-155 was induced by TNF-α in MC3T3-E1 cells. ► Knockdown of miR-155 partially mitigated the inhibition of TNF-α. ► miR-155 functions by directly targeting SOCS1. ► miR-155 augments SAPK/JNK signaling pathway.