Ginsenoside Rh2 inhibits osteoclastogenesis through down-regulation of NF-κB, NFATc1 and c-Fos

► Ginsenoside Rh2 inhibits RANKL induced osteoclast formation. ► ERK and NF-κB pathways were related with this inhibitory mechanism. ► Ginsenoside Rh2 prevents bone destruction in mouse model.