Strain-adaptive in silico modeling of bone adaptation - A computer simulation validated by in vivo micro-computed tomography data

► We developed a microstructural load-dependent remodeling algorithm for trabecular bone adaptation. ► The in silico algorithm is validated by experimental in vivo loading and ovariectomy data of the mouse. ► Both mechanical loading and osteoporotic bone loss are predicted with a maximum error of 12.1% in bone morphometric indices. ► Bone formation and resorption rates do not differ significantly in the loading but in the ovariectomy experiment.