Borage and fish oils lifelong supplementation decreases inflammation and improves bone health in a murine model of senile osteoporosis

► Fatty acids from sunflower origin exacerbate osteoporosis features in SAMP8 mice. ► Borage and fish diets prevent bone loss without affecting bone growth. ► Fish diet-induced bone rescue is correlated with fat mass gain. ► Borage and fish diets restore inflammatory parameters. ► Fish and borage diets affect bone remodeling markers.