WISE-2005: Bed-rest induced changes in bone mineral density in women during 60Â days simulated microgravity

► Bed-rest results in regional differences in losses of bone in women. ► The greatest effects on bone were seen at the hip and distal tibia. ► Little effect of the countermeasures was seen on bone loss. ► Losses in muscle mass and some changes in body composition were reduced by the exercise countermeasure.