Attenuated anabolic response to exercise in lamin A/C haploinsufficient mice

► The presence of lamin A/C is required for the anabolic effect of exercise on bone quality ► Absence of lamin A/C affects the response of β-catenin to exercise in Lmna+/− mice therefore reducing its anabolic effect on bone ► Using a model of exercise in lamin A/C-deficient mice, we have identified a new role for lamin A/C in bone biology