Tibial compression is anabolic in the adult mouse skeleton despite reduced responsiveness with aging

►Adult mice underwent tibial compression to test the effects of age on adaptation. ►2 groups received matching peak loads/strain based on that used in growing mice. ►Only the Load-Matched group increased cortical and cancellous bone mass. ►The adaptive response was reduced with aging in adults. ►Tibial compression recovered age-related bone mass to levels in growing mice.