Spatiotemporal delivery of bone morphogenetic protein enhances functional repair of segmental bone defects

► Hybrid BMP-2 delivery system consisting of nanofibrous mesh and alginate hydrogel. ► Compared efficacy of hybrid system to collagen sponge in repairing bone defects. ► Hybrid system significantly improved bone regeneration and biomechanical function. ► Nanofiber mesh tube was essential to guide an integrated pattern of bone formation.