High extracellular calcium-induced NFATc3 regulates the expression of receptor activator of NF-κB ligand in osteoblasts

► High calcium induced RANKL expression in osteoblasts via calcineurin/NFAT activation. ► Activated NFATc1 upregulates NFATc3 expression. ► NFATc3 binds the RANKL promoter and transactivates its expression.