Bisphosphonates in oncology

► Bisphosphonates are an integral part of treatment for patients with bone metastases from solid tumours and in multiple myeloma.► Prevention of skeletal morbidity with bisphosphonates has transformed the quality of life of patients with bone metastases. ► Bisphosphonates prevent bone loss associated with cancer treatments. However, selection criteria for intervention require further definition. ► Adjuvant use of bisphosphonates in early breast cancer may modify the disease course.