Fluvastatin does not prevent the acute-phase response to intravenous zoledronic acid in post-menopausal women

► Study investigated if statins prevent acute-phase response to aminobisphosphonates. ► Zoledronic acid increased pro-inflammatory cytokine levels in post-menopausal women. ► Zoledronic acid induced flu-like symptoms in >50% study participants. ► Fluvastatin did not prevent symptoms or cytokine release induced by zoledronic acid. ► Fluvastatin does not prevent the acute-phase response to zoledronic acid.