کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5898930 | 1568800 | 2016 | 8 صفحه PDF | دانلود رایگان |
- Concomitant thiazolidinedione + fibrate use was associated with a â¼1.5- to 2.5-fold increased risk of severe hypoglycemia.
- This increased risk generally manifested after the first month of concomitant use.
- Severe hypoglycemia occurs in some patients receiving a thiazolidinedione, even without concomitant exposure to insulin or a sulfonylurea.
- The apparent drug interaction between thiazolidinediones and fibrates is an underappreciated cause of severe hypoglycemia.
- Clinicians should be attuned to both immediate- and delayed-onset hypoglycemia in their patients treated concomitantly with thiazolidinediones and fibrates.
We conducted high-dimensional propensity score-adjusted cohort studies to examine whether thiazolidinedione use with a statin or fibrate was associated with an increased risk of severe hypoglycemia. We found that concomitant therapy with a thiazolidinedione + fibrate was associated with a generally delayed increased risk of severe hypoglycemia.
Journal: Diabetes Research and Clinical Practice - Volume 115, May 2016, Pages 60-67