کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5900300 | 1155642 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
DPP-IV inhibitory potential of naringin: An in silico, in vitro and in vivo study
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
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چکیده انگلیسی
The incretin based therapies are emerging class of antidiabetic drugs having two categories one is glucagone like peptide-1 (GLP-1) agonists and another one is dipeptidyl peptidase (CD26; DPP-IV) inhibitors. However, in DPP-IV inhibitors category only few compounds are commercially available and also having some undesirable effects. Therefore, in the present work we tried to explore a naturally occurring compound naringin for its potential DPP-IV inhibition and antidiabetic potential. It is noteworthy that this compound is abundantly present in the peels of Orange and thus may provide cost effective treatment for diabetes especially type 2 diabetes mellitus. In the present study we have conducted virtual docking study and observed tight binding of naringin, as shown by higher negative values of H Bond lengths, while in vitro DPP-IV inhibition assay has also shown better inhibition by naringin. In vivo study, in response to 10Â days administration of 40Â mg/kg of naringin twice daily to Wistar albino rats, inhibited the serum levels of DPP-IV activity, random glucose concentration with concomitant increase in insulin levels. All the comparisons were made with the standard commercially available drug sitagliptin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 97, Issue 1, July 2012, Pages 105-111
Journal: Diabetes Research and Clinical Practice - Volume 97, Issue 1, July 2012, Pages 105-111
نویسندگان
Hamendra Singh Parmar, Palak Jain, Digvijay Singh Chauhan, Mahesh Kumar Bhinchar, Vibhuti Munjal, Mohammed Yusuf, Krati Choube, Arpita Tawani, Vinita Tiwari, E. Manivannan, Anil Kumar,