کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5900606 1568823 2016 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Review articleEstrogens, inflammation and cognition
ترجمه فارسی عنوان
بازنگری مقاله ادرار، التهاب و شناخت
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی


- Low levels of estrogens has been linked to cognitive impairment.
- Oophorectomy and menopause are associated with a pro-inflammatory phenotype.
- Inflammation has also been implicated in the etiology of dementia.
- The relationship between low levels of estrogens and cognitive changes may be mediated by inflammatory processes.

The effects of estrogens are pleiotropic, affecting multiple bodily systems. Changes from the body's natural fluctuating levels of estrogens, through surgical removal of the ovaries, natural menopause, or the administration of exogenous estrogens to menopausal women have been independently linked to an altered immune profile, and changes to cognitive processes. Here, we propose that inflammation may mediate the relationship between low levels of estrogens and cognitive decline. In order to determine what is known about this connection, we review the literature on the cognitive effects of decreased estrogens due to oophorectomy or natural menopause, decreased estrogens' role on inflammation - both peripherally and in the brain - and the relationship between inflammation and cognition. While this review demonstrates that much is unknown about the intersection between estrogens, cognition, inflammation, we propose that there is an important interaction between these literatures.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Frontiers in Neuroendocrinology - Volume 40, January 2016, Pages 87-100
نویسندگان
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