کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5901043 1568902 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewExpression and function of growth hormone in the nervous system: A brief review
ترجمه فارسی عنوان
تجدید نظر و عملکرد هورمون رشد در سیستم عصبی: یک بررسی کوتاه
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی


- GH is expressed in neural tissues and acts as an autocrine/paracrine factor.
- GH treatment confers neuroprotection and plays a role in brain repair.
- GH has effects on neural functions, including mood and cognition.
- GH is involved in neurotransmission and neuromodulation.

There is increasing evidence that growth hormone (GH) expression is not confined exclusively to the pituitary somatotrophs as it is synthesized in many extrapituitary locations. The nervous system is one of those extrapituitary sites. In this brief review we summarize data that substantiate the expression, distribution and characterization of neural GH and detail its roles in neural function, including cellular growth, proliferation, differentiation, neuroprotection and survival, as well as its functional roles in behavior, cognition and neurotransmission. Although systemic GH may exert some of these effects, it is increasingly evident that locally expressed neural GH, acting through intracrine, autocrine or paracrine mechanisms, may also be causally involved as a neurotrophic factor.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 203, 1 July 2014, Pages 35-42
نویسندگان
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