کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5903002 | 1157043 | 2016 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Exercise and diet in the management of nonalcoholic fatty liver disease
ترجمه فارسی عنوان
ورزش و رژیم غذایی در مدیریت بیماری کبد چربی غیرالکلی
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کلمات کلیدی
ALTHOMA-IRIHTGHCC - HCCAST - آسپارتات ترانس آمینازalanine transaminase - آلانین ترانس آمینازhomeostasis model assessment of insulin resistance - ارزیابی مدل هومیوستاز مقاومت به انسولینaspartate transaminase - ترانس آمیناز آسپارتاتCognitive behavioral therapy - درمان رفتاری شناختیCBT - رفتار درمانی شناختی body mass index - شاخص توده بدنBMI - شاخص توده بدنیHepatocellular carcinoma - کارسینوم هپاتوسلولار(کارسینوم سلولهای استخوانی)
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver condition worldwide, and is projected to become the leading cause for liver transplantation in the United States as early as 2020. The mainstay of treatment remains lifestyle modification with diet and exercise recommendations, as although some pharmacological treatments such as glitazones and Vitamin E have shown benefit, there are concerns regarding long term safety. The evidence base for dietary interventions in NAFLD such as the Mediterranean diet, omega-3 polyunsaturated fatty acids and coffee is mainly derived from observational data with questionable validity. Where trials exist, they have shown benefit for surrogate outcomes such as hepatic steatosis and insulin resistance, but no trials have been conducted with salient clinical outcomes such as reduction in progression to chronic liver disease. Benefit in surrogate outcomes has also been seen for aerobic, anaerobic and combined modality exercise but it remains unclear if one type is superior. Furthermore, a reduction in sedentary time appears equally important. To provide a sound evidence base for lifestyle recommendations to people with NAFLD, longer duration trials of standardized dietary or exercise interventions, and testing various doses, types and with liver related outcomes, are essential.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Metabolism - Volume 65, Issue 8, August 2016, Pages 1172-1182
Journal: Metabolism - Volume 65, Issue 8, August 2016, Pages 1172-1182
نویسندگان
Suzanne E. Mahady, Jacob George,