کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5903512 | 1157083 | 2012 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Allelic variations in the vitamin D receptor gene, insulin secretion and parents' heights are independently associated with height in obese children and adolescents
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کلمات کلیدی
VDR geneGWAVDROGTTIFGIGTANCOVAAUC - AUCOral glucose tolerance test - آزمون تحمل گلوکز خوراکیimpaired glucose tolerance - اختلال تحمل گلوکزImpaired fasting glucose - اختلال قندخون ناشتاBody height - ارتفاع بدنHomeostasis model assessment - ارزیابی مدل HomostasisGenome-wide association - انجمن گسترده ژنومanalyses of covariance - تحلیل کوواریانسInsulin secretion - ترشح انسولینDiabetes mellitus - دیابت قندیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیLinkage disequilibrium - عدم تعادل پیوستگیObesity - مرض چاقیarea under the curve - منطقه تحت منحنیAdolescent - نوجوانیHOMA - هومSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتیدChild - کودکVitamin D receptor - گیرنده ویتامین D
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Polymorphisms in the VDR gene were reported to be associated with variations in intrauterine and postnatal growth and with adult height, but also with other traits that are strongly correlated such as the BMI, insulin sensitivity, insulin secretion and hyperglycemia. Here, we assessed the impact of VDR polymorphisms on body height and its interactions with obesity- and glucose tolerance-related traits in obese children and adolescents. We studied 173 prepubertal (Tanner's stage 1) and 146 pubertal (Tanner's stages 2-5) obese children who were referred for a weight-loss program. Three single nucleotide polymorphisms were genotyped: rs1544410 (BsmI), rs7975232 (ApaI) and rs731236 (TaqI). BsmI and TaqI genotypes were significantly associated with height in pubertal children, but the associations did not reach statistical significance in prepubertal children. In stepwise regression analyses, the lean body mass, insulin secretion, BsmI or TaqI genotypes and the father's and the mother's height were independently and positively associated with height in pubertal children. These covariables accounted for 46% of the trait variance. The height of homozygous carriers of the minor allele of BsmI was 0.65 z-scores (4Â cm) higher than the height of homozygous carriers of the major allele (PÂ =Â .0006). Haplotype analyses confirmed the associations of the minor alleles of BsmI and TaqI with increased height. In conclusion, VDR genotypes were significantly associated with height in pubertal obese children. The associations were independent from the effects of confounding traits, such as the body fat mass, insulin secretion, insulin sensitivity and glucose tolerance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Metabolism - Volume 61, Issue 10, October 2012, Pages 1413-1421
Journal: Metabolism - Volume 61, Issue 10, October 2012, Pages 1413-1421
نویسندگان
Daniela A.F. Ferrarezi, Naïma Bellili-Muñoz, Christiane Nicolau, Nadir Cheurfa, Isabel C. Guazzelli, Eliana Frazzatto, Gilberto Velho, Sandra M. Villares,