Differential nitric oxide levels in the blood and skeletal muscle of type 2 diabetic subjects may be consequence of adiposity: a preliminary study

We conclude that the decreased serum NO ∙ production in obese T2DM patients seems to be associated with adipose mass as lower adiposity was associated with normal NO ∙ which was reduced in the skeletal muscle of the non-obese T2DM patients. We suggest that the lower adiposity (and higher adiponectin) in non-obese T2DM could be responsible for differential levels of NO ∙ production and insulin resistance.