کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5903760 1157105 2012 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Basic ScienceCentral leptin and insulin administration modulates serum cytokine- and lipoprotein-related markers
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Basic ScienceCentral leptin and insulin administration modulates serum cytokine- and lipoprotein-related markers
چکیده انگلیسی

In most obese patients there is an inflammatory state characterized by lipid abnormalities, hyperleptinemia and hyperinsulinemia.ObjectiveThe objective was to identify mechanisms involved in leptin's role in the attenuation of the response to insulin using a proteomic approach.Material/MethodsWe studied the serum proteomic profile of rats treated by central leptin infusion followed by an injection of insulin. We analyzed the relationship between these proteins and serum cytokine and apolipoprotein levels.ResultsOut of 81 protein spots, intensity differences were found in 11, corresponding to 5 proteins: three isoforms of α1 macroglobulin; three of haptoglobin and serum amyloid P component-precursor. All of these are acute-phase proteins involved in inflammation and are correlated with cytokine levels. Additionally, two apolipoprotein E and two apolipoprotein A1 isoforms were identified and were found to correlate with LDL and HDL.ConclusionsOur results indicate that increased leptin and insulin levels change these circulating proteins, thus promoting systemic inflammation and changing lipid metabolism.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Metabolism - Volume 61, Issue 11, November 2012, Pages 1646-1657
نویسندگان
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