کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5904348 | 1157978 | 2015 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
l-Carnitine supplementation improved clinical status without changing oxidative stress and lipid profile in women with knee osteoarthritis
ترجمه فارسی عنوان
مکمل ال-کارنیتین بهبود وضعیت بالینی بدون تغییر استرس اکسیداتیو و لیپید در زنان مبتلا به استئوآرتریت زانو
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کلمات کلیدی
MDAVASHDL-CABTSANCOVATACLDL-CKnee osteoarthritis - استئوآرتریت زانوOsteoarthritis - استئوآرتریت(آرتروز)l-Carnitine - ال کارنیتینanalysis of covariance - تجزیه و تحلیل کوواریانسtriglyceride - تریگلیسریدOxidative stress - تنش اکسیداتیوWomen - زنbody mass index - شاخص توده بدنBMI - شاخص توده بدنیTotal antioxidant capacity - ظرفیت آنتی اکسیدانی کلhigh-density lipoprotein cholesterol - لیپوپروتئین پرچگالی یا اچدیالmalondialdehyde - مالون دی آلدهیدvisual analog scale - مقیاس آنالوگ بصریClinical status - وضعیت بالینیLipid profile - پروفایل چربیtotal cholesterol - کلسترول تامLow-density lipoprotein cholesterol - کلسترول لیپوپروتئین با چگالی کم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
Considering the pathologic importance of oxidative stress and altered lipid metabolism in osteoarthritis (OA), this study aimed to investigate the effect of l-carnitine supplementation on oxidative stress, lipid profile, and clinical status in women with knee OA. We hypothesized that l-carnitine would improve clinical status by modulating serum oxidative stress and lipid profile. In this randomized double-blind, placebo-controlled trial, 72 overweight or obese women with mild to moderate knee OA were randomly allocated into 2 groups to receive 750 mg/d l-carnitine or placebo for 8 weeks. Dietary intake was evaluated using 24-hour recall for 3 days. Serum malondialdehyde (MDA), total antioxidant capacity (TAC) and lipid profile, visual analog scale for pain intensity, and patient global assessment of severity of disease were assessed before and after supplementation. Only 69 patients (33 in the l-carnitine group and 36 in the placebo group) completed the study. l-Carnitine supplementation resulted in significant reductions in serum MDA (2.46 ± 1.13 vs 2.16 ± 0.94 nmol/mL), total cholesterol (216.09 ± 34.54 vs 206.12 ± 39.74 mg/dL), and low-density lipoprotein cholesterol (129.45 ± 28.69 vs 122.05 ± 32.76 mg/dL) levels compared with baseline (P < .05), whereas these parameters increased in the placebo group. Serum triglyceride, high-density lipoprotein cholesterol, and TAC levels did not change significantly in both groups (P > .05). No significant differences were observed in dietary intake, serum lipid profile, MDA, and TAC levels between groups after adjusting for baseline values and covariates (P > .05). There were significant intragroup and intergroup differences in pain intensity and patient global assessment of disease status after supplementation (P < .05). Collectively, l-carnitine improved clinical status without changing oxidative stress and lipid profile significantly in women with knee OA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 35, Issue 8, August 2015, Pages 707-715
Journal: Nutrition Research - Volume 35, Issue 8, August 2015, Pages 707-715
نویسندگان
Aida Malek Mahdavi, Reza Mahdavi, Sousan Kolahi, Maryam Zemestani, Amir-Mansour Vatankhah,