کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5904550 | 1158009 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genistein reduced insulin resistance index through modulating lipid metabolism in ovariectomized rats
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کلمات کلیدی
SDHOVXGSEASAMFASDCIPCPTCOXCHOLTNFαcDNA - cDNAComplementary DNA - DNA تکمیلیFatty acid synthetase - Synthetase اسید چربβ-oxidation - β-اکسیداسیونOvariectomy - اوفورکتومی، تخمدان برداریSignificance Analysis of Microarrays - تجزیه و تحلیل اهمیت MicroarraysGene-set enrichment analysis - تجزیه و تحلیل غنی سازی ژنOxidative stress - تنش اکسیداتیوtumor necrosis factor-α - تومور نکروز عامل αSham surgery - جراحی شامKEGG یا Kyoto Encyclopedia of Genes and Genomes - دایرة المعارف ژن ها و ژنوم کیوتو Kyoto Encyclopedia of Genes and Genomes - دایره المعارف ژنتیک ژن ها و ژنوم کیوتوMicroarray - ریزآرایهsuccinate dehydrogenase - سوکسیناد دهیدروژنازcytochrome c oxidase - سیتوکروم سی اکسیدازSham - شامMitochondrial function - عملکرد میتوکندریInsulin resistance - مقاومت به انسولینRat - موش صحراییGene ontology - هستیشناسی ژنیCarnitine palmitoyltransferase - کارنتین پالمیتیل ترانسفرازcholesterol - کلسترولestrogen receptors - گیرنده های استروژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Postmenopausal women are at higher risk for obesity and insulin resistance due to the decline of estrogen, but genistein, a phytoestrogen, may reduce the risks of these diet-related diseases. In this study, we hypothesized that supplemental genistein has beneficial effects on insulin resistance in an ovariectomized rat model by modulating lipid metabolism. Three weeks after a sham surgery (sham) or an ovariectomy (OVX), ovariectomized Sprague-Dawley rats were placed on a diet containing 0 (OVX group) or 0.1% genistein for 4 weeks. The sham rats were fed a high-fat diet containing 0% genistein and served as the control group (sham group). The ovariectomized rats showed increases in body weight and insulin resistance index, but genistein reduced insulin resistance index and the activity of hepatic fatty acid synthetase. Genistein was also associated with increased activity of succinate dehydrogenase and carnitine palmitoyltransferase and the rate of β-oxidation in the fat tissue of rats. The ovariectomized rats given genistein had smaller-sized adipocytes. Using gene-set enrichment analysis (GSEA) of microarray data, we found that a number of gene sets of fatty acid metabolism, insulin resistance, and oxidative stress were differentially expressed by OVX and reversed by genistein. This systemic approach of GSEA enables the identification of such consensus between the gene expression changes and phenotypic changes caused by OVX and genistein supplementation. Genistein treatment could help reduce insulin resistance through the amelioration of OVX-induced metabolic dysfunction, and the GSEA approach may be useful in proposing putative targets related to insulin resistance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Brought to you by:GAYATRI VIDYA PARISHAD COLLEGE OF ENGINEERING for Women Renewal due by 31 Dec 2017
Journal: Nutrition Research - Brought to you by:GAYATRI VIDYA PARISHAD COLLEGE OF ENGINEERING for Women Renewal due by 31 Dec 2017
نویسندگان
Joo Sun Choi, In-Uk Koh, Jihyun Song,