کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5904588 | 1158014 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intake of hot water-extracted apple protects against myocardial injury by inhibiting apoptosis in an ischemia/reperfusion rat model
ترجمه فارسی عنوان
دریافت سیب زمینی استخراج شده با آب گرم، از طریق مهار آپوپتوز در یک مدل موش ایسکمی / رت
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کلمات کلیدی
weaoxLDLDCMCHDTFACASAARTTC2,3,5-triphenyltetrazolium chloride - 2،3،5-trihenyltetrazolium chlorideMyocardial infarction - آنفارکتوس میوکاردTrifluoroacetic acid - اسید TrifluoroaceticInfarct size - اندازه انفارکتMyocardial ischemia/reperfusion - ایسکمی / رپرفیوژن میوکاردcoronary heart disease - بیماری عروق کرونر قلبTUNEL - تونلApoptosis - خزان یاختهایDichloromethane - دیکلورمتانApple - سیبInjury - صدمهhot water extract - عصاره آب گرمLAD - لادوOxidized low-density lipoprotein - لیپوپروتئین با چگالی کم اکسید شدهLow-density lipoprotein - لیپوپروتئین کم چگالی یا الدیال LDL - لیپوپروتئین کم چگالی(کلسترول بد)terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling - مارک نهایی با نام dUTP تخصیص داده شده توسط ترمینال deoxynucleotidyl transferase استarea at risk - منطقه در معرض خطر استborder zone - منطقه مرزیRat - موش صحراییinfarct area - ناحیه انفارکتleft anterior descending coronary artery - چپ قدامی نزولی عروق کرونر
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
Intakes of apple and its products are shown to reduce the risk of coronary heart disease by delaying occlusion of coronary arteries. In our previous study, we showed that apple pectin protected against myocardial injury by prohibiting apoptotic cascades in a rat model of ischemia/reperfusion. Thus, we hypothesized that water-extracted apple, into which apple pectin was released from the cell wall, might exhibit the same efficacy as apple pectin. To test this hypothesis, we fed rats either cold water- (400 mg kgâ1 dâ1) or hot water-extracted apples (HWEA; 40, 100, and 400 mg kgâ1 dâ1). Three days later, the rats were subjected to myocardial injuries by ligating the left anterior descending coronary artery (30 minutes), and subsequently, the heart (3 hours) reperfused by releasing the ligation. Only the rats that were supplemented with HWEA (400 mg kgâ1 dâ1) showed significant reductions in infarct size, which was 28.5% smaller than that of the control group. This infarct size reduction could be partly attributed to the prevention of steps leading to apoptosis. These steps are manifested by a higher Bcl-2/Bax ratio, lower procaspase-3 conversion to caspase-3, and inhibition of DNA nick generation, which reflects the extent of apoptosis. The findings indicate that HWEA supplementation reduces myocardial injury by inhibiting apoptosis under ischemia/reperfusion conditions. In conclusion, this study suggests that apple intake, specifically boiled apple, might reduce the risk of coronary heart disease by inhibiting postocclusion steps, such as myocardial injury after artery occlusion, as well as preocclusion steps, such as atherosclerotic plaque formation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 34, Issue 11, November 2014, Pages 951-960
Journal: Nutrition Research - Volume 34, Issue 11, November 2014, Pages 951-960
نویسندگان
Mi Young Kim, Sun Ha Lim, Jongwon Lee,