کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5904694 1158426 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics
ترجمه فارسی عنوان
ارتباطات سلولی و ناهمگنی در پویا پراکندگی انسولین جزیره پانکراس
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
Coordinated pulses of electrical activity and insulin secretion are a hallmark of the islet of Langerhans. These coordinated behaviors are lost when β cells are dissociated, which also leads to increased insulin secretion at low glucose levels. Islets without gap junctions exhibit asynchronous electrical activity similar to dispersed cells, but their secretion at low glucose levels is still clamped off, putatively by a juxtacrine mechanism. Mice lacking β cell gap junctions have near-normal average insulin levels, but are glucose intolerant due to reduced first-phase and pulsatile insulin secretion, illustrating the importance of temporal dynamics. Here, we review the quantitative data on islet synchronization and the current mathematical models that have been developed to explain these behaviors and generate greater understanding of the underlying mechanisms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Endocrinology & Metabolism - Volume 25, Issue 8, August 2014, Pages 399-406
نویسندگان
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