کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5907238 1160004 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sequences in the H19 ICR that are transcribed as small RNA in oocytes are dispensable for methylation imprinting in YAC transgenic mice
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Sequences in the H19 ICR that are transcribed as small RNA in oocytes are dispensable for methylation imprinting in YAC transgenic mice
چکیده انگلیسی
► Oocyte small RNA sequences mapped only to the H19 ICR among fifteen gametic DMRs. ► DNA sequences corresponding to the small RNAs were deleted from the H19 ICR. ► TgM were generated with beta-globin YAC carrying the mutant H19 ICR fragment. ► Methylation imprinting was normally established at the mutant H19 ICR. ► Deleted DNA sequences from the H19 ICR are dispensable for methylation imprinting.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 508, Issue 1, 15 October 2012, Pages 26-34
نویسندگان
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