Identification of candidate SNPs for drug induced toxicity from differentially expressed genes in associated tissues

► We present a bioinformatic approach to identify genes associated with drug toxicity. ► Twist - to identify genes affected by drugs and expressed in toxicity related tissue. ► Genetic variants in these genes were genotyped in 94 cancer patients. ► Variants in ABCA1 and ATM were associated with paclitaxel/carboplatin toxicity.