Coexisting role of fasting or feeding and dietary lipids in the control of gene expression of enzymes involved in the synthesis of saturated, monounsaturated and polyunsaturated fatty acids

► Upon feeding elongation and desaturation take place for fatty acid synthesis (FAS). ► After feeding, dietary lipids (DL) suppress saturated and monounsaturated synthesis. ► Elovl7 may be downregulated by insulin and this effect increases by DL. ► Regulation of elongases may have a Srebf-1c-independent pathway upon feeding. ► Upregulation by feeding of FAS does not compensate for the inhibitory effect of DL.