Attenuation of the acute inflammatory response by dual specificity phosphatase 1 by inhibition of p38 MAP kinase

- The role of DUSP1 on acute inflammatory response was investigated.
- p38 MAPK phosphorylation was limited by DUSP1.
- DUSP1 inhibited IL-6, TNF and COX2 expression in macrophages.
- Carrageenan-induced paw inflammation was enhanced in DUSP1 deficient mice.
- DUSP1 suppresses acute inflammatory response by inhibition of p38 MAPK.