Alzheimer-associated mutant ubiquitin impairs spatial reference memory

► UBB+ 1 mice display no gross neurological abnormalities during aging. ► UBB+ 1 mice show normal procedural motor-learning and motor coordination. ► UBB+ 1 mice show a subtle spatial learning deficit at 15 months of age. ► Intact forebrain proteasome function is important for cognitive function.