کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
592738 1453915 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Solvent selection effects on the transport of compounds through silicone membrane
ترجمه فارسی عنوان
اثرات انتخاب حلال بر انتقال ترکیبات از طریق غشای سیلیکون
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
چکیده انگلیسی


• Influence of various donor and receptor solutions was evaluated.
• Concentration of propylene glycol in the donor solution influenced the permeation.
• Key finding was various receptor solutions either enhanced or inhibited the permeation across silicone membranes.

This study evaluates the effects of donor and receptor solution composition on the transport of two model drugs, namely lidocaine and salicylic acid, across silicone membrane. Binary mixtures of buffer and propylene glycol (PG) were used as the donor vehicle and the movement of the two drugs was evaluated. The rate and extent of drug permeation was substantially influenced by the PG content in the binary mixtures with 40% PG exhibiting maximum impact. Modification of the receptor solution was also investigated whereby lidocaine permeation was reduced in a PG-based receptor phase, compared with ethanol, sub-micellar and micellar based receptor solutions. This difference was more pronounced for salicylic acid where alcohol-based receptor solutions prevented permeation whilst surfactant based (sub-micellar and micellar) receptor phases appeared to promote permeation. This enhancement is proposed to be a consequence of the drag, or pull, effect of the surfactant adsorbed on the silicone membrane in the receptor phase.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Volume 458, 20 September 2014, Pages 96–100
نویسندگان
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