A novel approach for the use of hyaluronic acid-based hydrogel nanoparticles as effective carriers for transdermal delivery systems

► A novel way for the use of hydrogel NPs in transdermal delivery system is suggested. ► In vitro and in vivo skin penetration experiments are conducted with hydrogel NPs. ► The type of dispersion medium affects the capability of NPs for the skin penetration. ► Hyaluronic acid-based hydrogel NPs in an oil effectively penetrate into a skin layer.