کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5942491 | 1574712 | 2016 | 9 صفحه PDF | دانلود رایگان |
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- 1-h post-load plasma glucose >125 mg/dl may identify a subset of individuals at higher cardiovascular risk in pre-diabeti subjects (HbA1c 5.7-6.4).
Background and aimsEvidence suggests that combining 1-hour plasma glucose â¥155 mg/dl during an oral glucose tolerance test (OGTT) with glycosylated hemoglobin (HbA1c) significantly increases their predictive power for incident diabetes, while their individual and joint associations with cardio-metabolic risk factors remain undefined. Herein, we evaluated whether 1-hour post-load plasma glucose â¥155 mg/dl combined with HbA1c may identify pre-diabetic individuals with a higher cardio-metabolic risk.MethodsAnthropometric and metabolic characteristics, insulin sensitivity and insulin secretion assessed by OGTT-derived indexes, carotid intima-media thickness (IMT), pulse pressure, and rate pressure product were evaluated in 1495 individuals.ResultsAs compared with subjects with 1-hour post-load glucose <155 mg/dl, individuals with 1-hour post-load glucose â¥155 mg/dl exhibited a significantly worse cardio metabolic profile, both in the group with HbA1c <5.7%, and in the group with prediabetes (HbA1c 5.7-6.4%). Specifically, in both groups, subjects with 1-hour post-load glucose â¥155 mg/dl had higher fasting and 2-h post-load glucose (p < 0.0001 for all in both groups), higher HOMA-IR (p < 0.0001 in both groups), and carotid IMT (p = 0.05 in the group with HbA1c <5.7% and p = 0.03 in the group HbA1c 5.7-6.4%), as well as lower Matsuda index, insulinogenic index and disposition index (p < 0.0001 in both groups), and lower insulin-stimulated glucose disposal (p < 0.0001 in the group with HbA1c <5.7% and p = 0.03 in the group HbA1c 5.7-6.4%).ConclusionsHyperglycemia at 1-hour during an OGTT may be a useful tool to identify a subset of individuals within HbA1c-defined glycemic categories at higher risk of developing type 2 diabetes and cardiovascular disease.
Journal: Atherosclerosis - Volume 253, October 2016, Pages 61-69