کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5942502 1574712 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Circulating angiotensin converting enzyme 2 activity as a biomarker of silent atherosclerosis in patients with chronic kidney disease
ترجمه فارسی عنوان
فعالیت آنزیم 2 آنژیوتانسین تبدیل آنزیم 2 به عنوان بیومارکر آترواسکلروز خاموش در بیماران مبتلا به بیماری مزمن کلیه
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


- Baseline circulating angiotensin converting enzyme 2 is an independent biomarker of territories with plaques at 2 years.
- Increased baseline ACE2 is associated with all-cause mortality at 2 years.
- ACE2 as a predictor for silent atheromatosis over 2-year follow-up in chronic kidney disease (CKD) patients.

Background and aimsCirculating Angiotensin Converting Enzyme 2 (ACE2) activity in chronic kidney disease (CKD) patients without previous history of cardiovascular disease (CVD) has been associated with classical risk factors (older age, diabetes and male gender). Furthermore, silent atherosclerosis has been described as a pathological link between CKD and CVD. We analyzed baseline ACE2 activity in non-dialysis CKD stages 3-5 (CKD3-5) patients as a biomarker of renal progression, silent atherosclerosis and CV events after 2 years of follow-up.MethodsProspective study of 1458 CKD3-5 subjects without any previous CV event included in the Spanish multicenter NEFRONA study. Association between baseline circulating ACE2 activity and renal parameters, carotid/femoral echography, atheromatous disease, ankle-brachial index, intima-media thickness, need of renal replacement therapy, cardiovascular events and mortality at 24 months of follow-up were analyzed.ResultsPatients with an increase in the number of territories with plaques at 24 months showed significantly higher levels of baseline ACE2 activity as compared to stable patients (29.6 (20.6-47.6)RFU/μL/h versus 35.7 (24.5-56), p < 0.001). Multivariate linear regression analysis showed that male gender, pathological ankle-brachial index and progressive silent atherosclerosis defined as an increased number of territories with plaques at 24 months were associated with increased baseline ACE2 activity. Male gender, older age, diabetes, smoking and increased baseline circulating ACE2 were independent predictors of atherosclerosis at 24 months of follow-up.ConclusionsIn CKD3-5 patients, higher circulating ACE2 activity at baseline is associated with higher risk for silent atherosclerosis, suggesting that ACE2 may serve as a biomarker to predict CV risk before CVD is established.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 253, October 2016, Pages 135-143
نویسندگان
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