Self-assembly of N-acyl derivatives of gemcitabine at the air/water interface and the formation of nanoscale structures in water

► Two novel amphiphilic lipid derivatives of gemcitabine. ► Langmuir monolayer behavior of the derivatives depending on the lipid chains. ► Nanofibers, vesicles and nanotubes formed from the derivatives in water. ► Worm-like micelles, rice-like and spherical vesicles, and leaf-like nanostructures.