کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5944693 1172345 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dectin-1 deficiency does not affect atherosclerosis development in mice
ترجمه فارسی عنوان
کمبود دکستین-1 بر روی رشد سلولهای آترواسکلروز در موش تاثیر نمی گذارد
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


- Hematopoietic dectin-1 deficiency has no effect on atherosclerotic lesions in mice.
- Mouse macrophages fail to respond to vimentin.
- Dectin-1 is dispensable for development of atherosclerosis.

ObjectiveRecent data suggest the involvement of dectin-1 in atherosclerosis through regulation of local reactive oxygen species production. The aim of the current study was to assess the effect of dectin-1 deficiency on atherosclerotic plaque development.MethodsUsing immunohistochemistry dectin-1 expression was observed on foamy macrophages in atherosclerotic lesions in mice. Following lethal irradiation LDLR−/− mice were reconstituted with bone marrow from either wild type or dectin-1−/− mice. After recovery, mice were fed a high fat diet for 9 weeks and atherosclerotic lesions were analyzed.Results and conclusionOverall, we found no significant differences in plaque size or severity between the groups. Also no differences were observed in granulocyte or macrophage composition of the plaques or in the ability to produce reactive oxygen species by macrophages from both groups. Dectin-1 is dispensable for the development of atherosclerotic lesions in mice.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 239, Issue 2, April 2015, Pages 318-321
نویسندگان
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