کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5946352 1172358 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Variability and reproducibility of carotid structural and functional parameters assessed with transcutaneous ultrasound - Results from the SAPALDIA Cohort Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Variability and reproducibility of carotid structural and functional parameters assessed with transcutaneous ultrasound - Results from the SAPALDIA Cohort Study
چکیده انگلیسی


- Reproducibility of all carotid structural and functional parameters was analysed.
- Data quality was validated within the SAPALDIA3 Cohort study setting.
- Structural parameters have an excellent reproducibility.
- Functional indices have a good reproducibility.
- Reproducibility was comparable to the highest standards in epidemiological studies.

ObjectiveCarotid intima media thickness (CIMT) and local stiffness are vascular biomarkers of atherosclerotic burden. We investigated the variability and reproducibility of clinically relevant structural (CIMT, lumen diameter) and functional parameters (strain, distensibility, compliance, β-stiffness index, Peterson's elastic modulus and Young's elastic modulus) measured in B-mode ultrasound sequences of the common carotid artery in the second follow up of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases In Adults (SAPALDIA3).MethodsUltrasound sequential images were examined twice over a 1 cm segment across at least one heart cycle in 165 SAPALDIA3 participants. To assess variability and reproducibility of structural and functional parameters, individual coefficients of variation (CV), intraclass correlation (ICC), Bland-Altman plots and mixed effect regressions were used.ResultsICCs of repeated examinations ranged between 0.67 and 0.77 for blood pressure indices, between 0.87 and 0.97 for structural properties and between 0.75 and 0.79 for functional parameters. CV was lowest in structural parameters (1.6-4.6%), followed by blood pressure (5.1-7.9%) and functional indices (11.0-13.1%). Variations in all parameters were predominantly explained by subjects (>74% in functional, >82% in structural properties). Bland-Altman plots for functional indices showed mean and standard deviation of the respective mean value of 4.2(19.6)% for strain, 1.9(24.4)% for distensibility, 2.4(22.2)% for compliance, 3.0(24.4)% for β-stiffness index, 0.9(25.7)% for Peterson's elastic modulus and 1.2(27.9)% for Young's elastic modulus.ConclusionThe results show that SAPALDIA3 measurements of transcutaneous ultrasound examinations have an excellent reproducibility of structural parameters and a good reproducibility of functional indices.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 231, Issue 2, December 2013, Pages 448-455
نویسندگان
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