کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5946622 | 1172360 | 2014 | 7 صفحه PDF | دانلود رایگان |
- Ezetimibe increased the removal from plasma of labeled chylomicron-like emulsions in subjects with coronary disease.
- Effects of ezetimibe 10Â mg upon emulsion intravascular kinetics were similar to 20Â mg simvastatin dosage.
- Similar increments on plasma kinetics were seen with ezetimibe 10Â mg associated with simvastatin 20Â mg or simvastatin 80Â mg.
ObjectiveReductions on the clearance from plasma of chylomicrons are associated with atherosclerosis. Statins improve the removal from plasma of chylomicrons in a dose dependent manner. There is controversy whether ezetimibe modifies the plasma clearance of chylomicrons. Effects of ezetimibe alone or in combination with simvastatin were compared with low and high dose of the latter, upon the kinetics of a chylomicron-like emulsion in coronary heart disease (CHD) patients.Methods25 CHD patients were randomized for treatment with ezetimibe 10 mg (group 1) or simvastatin 20 mg (group 2) with progression to ezetimibe + simvastatin 10/20 mg or simvastatin 80 mg, respectively. Kinetic studies were performed at baseline and after each treatment period of 6 weeks. The fractional catabolic rates (FCR) of the emulsion labeled with 14C-CE and 3H-TG, that represent respectively chylomicron remnant and triglyceride removal, were calculated. Comparisons were made by ANOVA.ResultsThe 14CE-FCR in group 1 were 0.005 ± 0.004, 0.011 ± 0.008 and 0.018 ± 0.005 minâ1 and in group 2 were 0.004 ± 0.003, 0.011 ± 0.008 and 0.019 ± 0.007 minâ1 respectively at baseline, after 6 and 12 weeks (p < 0.05 vs. baseline, and 6 vs. 12 weeks). The 3H-TG-FCR in group 1 were 0.017 ± 0.011, 0.024 ± 0.011 and 0.042 ± 0.013 minâ1 and in group 2 were 0.016 ± 0.009, 0.022 ± 0.009 and 0.037 ± 0.012 minâ1 at baseline, after 6 and 12 weeks (p < 0.05 vs. baseline, and 6 vs. 12 weeks). There were no differences between groups in time.ConclusionBoth treatments increased similarly the removal from plasma of chylomicron and remnants in CHD patients.
Journal: Atherosclerosis - Volume 233, Issue 1, March 2014, Pages 319-325