کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5946664 | 1172360 | 2014 | 6 صفحه PDF | دانلود رایگان |
- In children from MetS+ families, percent ucOC was higher than in children from MetSâ families.
- The undercarboxylated form of OC is related to common cardiovascular risk markers in children at risk for cardiovascular disease.
BackgroundThe undercarboxylated form of osteocalcin (ucOC) is an emerging marker of cardiovascular disease. It is unknown if ucOC in related to common cardiovascular risk markers in children. In offspring of families with and without metabolic syndrome (MetS+ and MetSâ families), we assessed whether ucOC was related to a continuous metabolic syndrome score (MetS score) and to carotid intima-media thickness (cIMT).MethodsucOC and total OC, MetS score and cIMT were assessed in 203 asymptomatic prepubertal children (age 7.6 ± 0.1 yr; 49% girls), of whom 99 were from MetS+ families.ResultsIn children from MetS+ families, percent ucOC was higher than in children from MetSâ families (p < 0.01). In offpring from MetS+ families, higher ucOC and especially higher percent ucOC was independently associated with both the MetS score and cIMT (both p â¤Â 0.01).ConclusionsThe undercarboxylated form of OC is related to common cardiovascular risk markers in children at risk for cardiovascular disease.
Journal: Atherosclerosis - Volume 233, Issue 1, March 2014, Pages 272-277