کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5947069 1574723 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A difference in systolic blood pressure between arms is a novel predictor of the development and progression of diabetic nephropathy in patients with type 2 diabetes
ترجمه فارسی عنوان
اختلاف فشار خون سیستولیک بین بازوها پیش بینی کننده جدیدی از پیشرفت و پیشرفت نفروپاتی دیابتی در بیماران مبتلا به دیابت نوع 2 است
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


- A difference in SBP was independently associated with change in urinary albumin excretion.
- A difference in SBP was associated with an increased hazard of development of albuminuria.
- A difference in SBP is a predictor of diabetic nephropathy in patients with type 2 diabetes.

ObjectiveRecent studies have suggested that a difference in systolic blood pressure (SBP) between arms is associated with both vascular disease and mortality. The aim of this study was to investigate the relationship between a difference in SBP between arms and change in urinary albumin excretion or development of albuminuria in patients with type 2 diabetes.MethodsWe measured SBP in 408 consecutive patients with type 2 diabetes, and calculated a difference in SBP between arms. We performed follow-up study to assess change in urinary albumin excretion or development of albuminuria, mean interval of which was 4.6 ± 1.7 years. We then evaluated the relationship of a difference in SBP between arms to diabetic nephropathy using multiple regression analysis and multiple Cox regression model.ResultsMultiple regression analyses demonstrated that a difference in SBP between arms was independently associated with change in urinary albumin excretion (β = 0.1869, P = 0.0010). Adjusted Cox regression analyses demonstrated that a difference in SBP between arms was associated with an increased hazard of development of albuminuria; hazard ratio was 1.215 (95% confidence interval 1.077-1.376). Moreover, the risk of development of albuminuria was increased in patients with a difference in SBP of equal to or more than 10 mmHg between arms; hazard ratio was 4.168 (95% confidence interval 1.478-11.70).ConclusionA difference in SBP between arms could be a novel predictor of the development and progression of diabetic nephropathy in patients with type 2 diabetes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 230, Issue 2, October 2013, Pages 198-201
نویسندگان
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