Acrolein-conjugated low-density lipoprotein induces macrophage foam cell formation

► Acrolein-conjugated LDL (Acro-LDL) was prepared by incubation of LDL with acrolein. ► The mobility of Acro-LDL determined by agarose gel electrophoresis was increased. ► Acro-LDL-induced higher cholesterol accumulation in macrophages than oxidized LDL. ► Acro-LDL uptake was mediated by scavenger receptor class A type 1 (SR-A1). ► Cholesterol in Acro-LDL was accumulated in lipid droplets of macrophages.