کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5947287 1172367 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protein tyrosine phosphatase inhibition down-regulates ligand-induced ABCA1 expression
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Protein tyrosine phosphatase inhibition down-regulates ligand-induced ABCA1 expression
چکیده انگلیسی


- Certain phosphatase inhibitors down-regulate ligand-induced ABCA1 expression.
- This occurs through protein tyrosine, but not serine/threonine, phosphatases.
- Down-regulation is predominantly a transcriptional effect.
- Protein tyrosine phosphatase inhibition decreases LXR/RXR promoter activity.

ObjectiveATP-binding cassette transporter (ABC)-A1 is an important protein of cholesterol homoeostasis and atherosclerosis as it is the major lipid transporter responsible for the export of cholesterol from cells. Many studies have examined kinase regulation of ABCA1 expression. In contrast, very little is known about whether dephosphorylation events play a role in ABCA1 expression. In this study, we explored the involvement of phosphatases in the regulation of ABCA1 expression.Methods and resultsWe observed that general protein tyrosine phosphatase inhibitors ablated ABCA1 protein and mRNA when stimulated with synthetic ligands. This effect is transcriptional, and appears to involve the nuclear receptor, retinoid X receptor (RXR).ConclusionOur data demonstrate that inhibition of protein tyrosine phosphatases down-regulates ABCA1 expression, indicating a new level of regulation of a key protein in cholesterol export.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 228, Issue 2, June 2013, Pages 362-369
نویسندگان
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