کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5947854 1172374 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study
چکیده انگلیسی


- We tested association of SNPs at the 2q36.3-IRS1 with subclinical atherosclerosis.
- SNPs at this locus were not associated with atherosclerosis in Framingham Heart Study.
- Alternative approaches are required to test the insulin resistance-atherosclerosis association.

ObjectiveCommon variants at the 2q36.3-IRS1 locus are associated with insulin resistance (IR), type 2 diabetes (T2D) and coronary artery disease (CAD) in large-scale association studies. We tested the hypothesis that variants at this locus are associated with subclinical atherosclerosis traits.MethodsWe studied 2740 Framingham Heart Study participants (54.9% women; mean age 57.8 years) with measures of coronary artery or abdominal aortic calcium, internal and common carotid intima-media thickness, and ankle-brachial index (ABI). We tested 1) four SNPs previously shown to be associated with IR (rs2972146, rs2943650), T2D (rs2943641) or CAD (rs2943634) and 2) any SNP at 2q36.3-IRS1, for association with subclinical atherosclerosis traits, adjusting for atherosclerosis risk factors. We set type 1 error rate for test 1) as 0.05/5 traits = P < 0.01, and for test 2) as 0.05 divided by the effective number of independent tests, divided by 5 for the number of traits analyzed.ResultsWe found no association between the four known SNPs and subclinical atherosclerosis, but identified one SNP (rs10167219, r2 with rs2943634 = 0.07) at 2q36.3 that was significantly associated with ABI (corrected P = 0.009). However, rs10167219 was not associated with ABI (P = 0.70) in 35,404 participants in a published ABI association study.ConclusionCommon variants at the 2q36.3-IRS1 locus were not associated with subclinical atherosclerosis traits in this study which was adequately powered to find associations with moderate effect size. Although IR and T2D may be mechanistically linked to CAD via subclinical atherosclerosis, an alternate mechanism for the IR-T2D-CAD associations at 2q36.3-IRS1 must be postulated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 229, Issue 1, July 2013, Pages 149-154
نویسندگان
, , , , , , , , , ,